SKP2B OVEREXPRESSION ALTERS A PROHIBITIN-P53 AXIS AND THE TRANSCRIPTION OF PAPP-A, THE PROTEASE OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4.

Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.

We previously reported that the degradation of prohibitin Stove Ignition Switch by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53.We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased proteolytic cleavage of the insulin-like growth factor binding protein 4 (I

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5G highway tunnel deployment scheme and performance verification

The scheme of deploying highway tunnel in 3.5 GHz typical frequency band of 5G was systematically analyzed.And the performance of the new antenna and the Hand and Nail Care new leaky cable deployed for highway tunnel were comprehensively evaluated by RSRP,SINR,and rate distribution.The coverage performance,safety requirements,cost and other aspects

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